Product Name :
2-Trifluoromethylindole (CAS 51310-54-4)

Synonym :
2-(trifluoromethyl)-1 H-Indole

Application :

CAS:
51310-54-4

Purity:
≥96%

Molecular Weight:
185.15

Formula :
C9H6F3N

Physical state:
Solid

solubility :
Soluble in water (slightly).

Shipping Condition :
Store at room temperature

Melting point:
106-110° C

SMILES:
C1=CC=C2C(=C1)C=C(N2)C(F)(F)F

References:
:Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083). | Zhou, HJ., et al. 2015. J Med Chem. 58: 9480-97. PMID: 26565666Electrophilic trifluoromethylation of carbonyl compounds and their nitrogen derivatives under copper catalysis.Dichlorodicyclohexylsilane Chemscene | Prieto, A.Boc-NH-C4-Br manufacturer , et al. 2016. Chem Commun (Camb). 52: 869-81. PMID: 26571150Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: Effects on potency and mode of activity. | Trabbic, CJ., et al. 2016. Eur J Med Chem. 122: 79-91. PMID: 27343855Synthesis and Reactions of 3-Halogenated 2-CF3-Indoles. | Muzalevskiy, VM., et al. 2022. Molecules. 27: PMID: 36557954Novel indole-ring formation by thermolysis of 2-(N-acylamino)-benzylphosphonium salts. Effective synthesis of 2-trifluoromethylindoles | Kazuyuki Miyashita, Katsunori Kondoh, Katsutoshi Tsuchiya, Hideto Miyabe and Takeshi Imanishi. 1996,. J. Chem. Soc., Perkin Trans. 1,: 1261-1268.Recent developments in indole ring synthesismethodology and applications | . 2000,. J. Chem. Soc., Perkin Trans.PMID:33709661 1,: 1045-1075.Synthesis of 2-trifluoromethyl indoles via visible-light induced intramolecular radical cyclization | Xichang Dong, Yumin Hu, Tiebo Xiao and Lei Zhou*. 2015,. (Communication) RSC Adv.,. 5,: 39625-39629.Fischer Reaction with 2-Perfluoroalkylated Cyclic Imines An Efficient Route to 2-Perfluoroalkyl-Substituted Tryptamines and Their Derivatives and Homologues | , et al. September 2015. European Journal of Organic Chemistry. Volume2015, Issue29: Pages 6479-6488.Palladium-catalyzed cyclization reaction of N-(2-Haloaryl)alkynylimines: Synthesis of 3-acylindoles using water as the sole solvent and oxygen source | and An-An Zhang, Tuanjie Meng, Wenli Wang, Xueli Liu, Yupei Zhu, Lantao Liu. April 2020. Applied Organometallic Chemistry. Volume34, Issue4: e5513.Pd-catalyzed coupling of arylamines and 2-bromo-3,3,3-trifluoropropene | T Kino, Y Nagase, Y Horino, T Yamakawa – Journal of Molecular Catalysis A …, 2008 – Elsevier. 3 March 2008,. Elsevier Journal of Molecular Catalysis A: Chemical. Volume 282, Issues 1–2,: Pages 34-51.Copper catalysed domino decarboxylative cross coupling-cyclisation reactions: synthesis of 2-arylindoles | T Ponpandian, S Muthusubramanian – Tetrahedron Letters, 2012 – Elsevier. 8 8 August 2012, 2012,. Tetrahedron Letters. Volume 53, Issue 32,: Pages 4248-4252.