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CASE REPORT Key cutaneous anaplastic large-cell lymphoma – Case report*Linfoma reduce eo prim io de grandes c ulas anapl icas – Relato de casoLuciana Silveira Rabello de Oliveira1 Maira Gomes MonteiroDOI: http://dx.doi.org/10.1590/abd1806-4841.Abstract: Major cutaneous anaplastic large-cell lymphoma is a part of the spectrum of CD30+ lymphoproliferative cutaneous processes, characterized by single or multifocal nodules that ulcerate, are autoregressive and recurrent. Extracutaneous dissemination could occur, in particular to regional lymph nodes. Histology shows a diffuse, non-epidermotropic infiltrate , anaplastic significant lymphoid cells of immunohistochemistry CD30+, CD4+, EMA-/+, ALK-, CD15- and TIA1-/+. Prognosis is excellent and will not depend on lymphatic invasion. Radiotherapy, removal from the lesion and/or low-dose methotrexate will be the therapies of decision. The present study reports the case of.