Product Name :
TEF1 Recombinant Rabbit Monoclonal Antibody [JE52-71]
Predicted band size :
48 kDa
Observed band size :
48 kDa
Synonyms:
AA antibody Atrophia areata peripapillary chorioretinal degeneration antibody NTEF 1 antibody NTEF-1 antibody NTEF1 antibody Protein GT IIC antibody Protein GT-IIC antibody REF 1 antibody REF1 antibody SV40 transcriptional enhancer factor antibody 展开
Function :
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC ‘enhansons’ (5′-GTGGAATGT-3′) and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human TEF1 aa 1-50 / 426.55685-58-0 Data Sheet
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
JE52-71
RRID:
AB_3071061
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Methyl (S)-3-bromo-2-methylpropanoate Formula Aliquot store at -20℃.PMID:33719963 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
48 kDa
Positive control :
SiHa cell lysate, Hela cell lysate, human colon cancer tissue using anti-商品名 antibody. The section was pre-treated using heat mediated antigen retrieval, rat skeletal muscle tissue using anti-商品名 antibody. The section was pre-treated using heat mediated antigen retrieval.