Product Name :
Phospho-MDM2 (S166) Recombinant Rabbit Monoclonal Antibody [JE64-20]
Predicted band size :
55 kDa
Observed band size :
110/140 kDa
Synonyms:
ACTFS antibody Double minute 2 protein antibody E3 ubiquitin-protein ligase Mdm2 antibody Hdm 2 antibody Hdm2 antibody HDMX antibody MDM 2 antibody MDM2 antibody MDM2 oncogene E3 ubiquitin protein ligase antibody Mdm2 p53 E3 ubiquitin protein ligase homolog antibody 展开
Function :
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic phosphopeptide corresponding to residues surrounding Ser166 of human MDM2.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB
Coupling :
unconjugated
Clone number:
JE64-20
RRID:
AB_3072903
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Formula of 6-Bromo-8-fluoroisoquinolin-1(2h)-one Aliquot store at -20℃.Nα,Nα-Bis(carboxymethyl)-L-lysine supplier Avoid repeated freeze / thaw cycles.PMID:33502502
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 55 kDa
Positive control :
A549 cell lysate.