Product Name :
c-Fos Recombinant Rabbit Monoclonal Antibody [PSH07-51]
Predicted band size :
Observed band size :
Synonyms:
Activator protein 1 antibody AP 1 antibody C FOS antibody Cellular oncogene c fos antibody Cellular oncogene fos antibody FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS) antibody FBJ murine osteosarcoma viral oncogene homolog antibody FBJ murine osteosarcoma viral v fos oncogene homolog antibody FBJ Osteosarcoma Virus antibody FOS antibody 展开
Function :
Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It is encoded in humans by the FOS gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus). It is a part of a bigger Fos family of transcription factors which includes c-Fos, FosB, Fra-1 and Fra-2. It has been mapped to chromosome region 14q21→q31. c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts extracellular signals into changes of gene expression. It plays an important role in many cellular functions and has been found to be overexpressed in a variety of cancers.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within human c-Fos aa 221-270.
Species reactivity:
Human, Mouse, Rat
Verify application:
IHC-P, IF-Cell, ChIP
Coupling :
unconjugated
Clone number:
PSH07-51
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.1450835-21-8 manufacturer Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.4-Methoxy-2-methylpyrimidin-5-amine web 05% Sodium Azide.PMID:33733301
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 41 kDa
Positive control :
Human brain tissue, mouse brain tissue, mouse hippocampus tissue, HeLa cells serum starved for 40 hours then add 20% FBS for 2 hours, RAW264.7 cells serum starved for 16 hours then add 20% FBS for 4 hours, C6 cells serum starved for 16 hours then add 10% FBS for 30 minutes.