Product Name :
WTAP Mouse Monoclonal Antibody [B6-B6]
Predicted band size :
Observed band size :
Synonyms:
DKFZp686F20131 antibody Female-lethal(2)D homolog antibody FL2D_HUMAN antibody hFL(2)D antibody KIAA0105 antibody MGC3925 antibody Mum2 antibody OTTHUMP00000017522 antibody OTTHUMP00000017523 antibody PNAS 132 antibody 展开
Function :
Wilms’ tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms’ tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (Wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles where it regulates the G2/M cell cycle transition by binding to the 3′ UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Purified recombinant fragment of human WTAP (AA: 91-201) expressed in E.Thalidomide-4-OH web Coli.Price of 2H-Pyrano[3,2-c]pyridin-4(3H)-one
Species reactivity:
Human, Monkey
Verify application:
WB, ICC, IHC-P, FC
Coupling :
unconjugated
Clone number:
B6-B6
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
4℃; -20℃ for long term storage.PMID:33475051
Storage buffer solution:
Purified antibody in PBS with 0.05% sodium azide.
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
55 kDa
Positive control :
Human WTAP recombinant protein, WTAP-hIgGFc transfected HEK293 cell lysate, MCF-7, Hela, K562, Hek293, A549, HepG2, Jurkat, Cos7, human cervical cancer tissue, human endometrial cancer tissue.