Product Name :
Phospho-STAT3 (Y705) Recombinant Rabbit Monoclonal Antibody [SZ43-01]
Predicted band size :
88 kDa
Observed band size :
88 kDa
Synonyms:
1110034C02Rik antibody Acute Phase Response Factor antibody Acute-phase response factor antibody ADMIO antibody APRF antibody AW109958 antibody DNA binding protein APRF antibody FLJ20882 antibody HIES antibody MGC16063 antibody 展开
Function :
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion.2,3-Dibromopropene Chemscene
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic phospho-peptide corresponding to residues surrounding Tyr705 of human STAT3.5-Ethynylpyridine-2-carbaldehyde custom synthesis
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, IP
Coupling :
unconjugated
Clone number:
SZ43-01
RRID:
AB_3069682
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33485667 Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 88 kDa
Positive control :
HeLa treated with 50ng/mL IFN alpha 1 for 30 minutes whole cell lysate, Jurkat treated with 50ng/mL IFN alpha 1 for 30 minutes whole cell lysate, A431 treated with 100ng/mL EGF for 30 minutes whole cell lysate, human lung tissue, Hela cell lysate, SK-Br-3 cell lysate, human kidney tissue, mouse skeletal muscle tissue.